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Philippe Gros Selected Research

pantetheinase (pantetheine hydrolase)

1/2016Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
8/2011Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
8/2010Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.
8/2010Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
3/2007Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.

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Philippe Gros Research Topics

Disease

35Infections
01/2020 - 04/2002
15Malaria
01/2020 - 11/2002
7Cerebral Malaria
01/2020 - 01/2012
7Anemia
01/2020 - 05/2003
7Neural Tube Defects (Exencephaly)
01/2018 - 03/2007
6Neuroinflammatory Diseases
12/2020 - 01/2013
5Neoplasms (Cancer)
12/2019 - 11/2003
5Colorectal Neoplasms (Colorectal Cancer)
12/2019 - 03/2010
4Inflammation (Inflammations)
12/2019 - 03/2010
3Tuberculosis (Tuberculoses)
01/2021 - 03/2009
3Colitis-Associated Neoplasms
12/2019 - 03/2010
3Iron Overload
01/2017 - 09/2005
3Cystinosis
01/2016 - 08/2010
3Pyruvate Kinase Deficiency of Red Cells
10/2009 - 07/2007
2Colitis
12/2020 - 03/2010
2Splenomegaly
01/2017 - 03/2004
2Virus Diseases (Viral Diseases)
12/2014 - 09/2012
2Communicable Diseases (Infectious Diseases)
09/2014 - 02/2004
2Parasitemia
08/2010 - 03/2007
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
01/2020
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2017
1Nematode Infections
10/2017
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2017
1Ganglion Cysts (Ganglion)
02/2016
1Falciparum Malaria (Plasmodium falciparum Malaria)
01/2016
1Sclerosis
03/2015
1Autoimmune Diseases (Autoimmune Disease)
08/2014
1Congenital Abnormalities (Deformity)
05/2014
1Methylenetetrahydrofolate reductase deficiency
05/2014
1Heart Diseases (Heart Disease)
05/2014
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
07/2011
1Carcinogenesis
06/2011
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2009
1Stroke (Strokes)
02/2008
1Pulmonary Tuberculosis
01/2008
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2007
1Hemolytic Anemia
07/2007

Drug/Important Bio-Agent (IBA)

26Proteins (Proteins, Gene)FDA Link
12/2020 - 05/2003
9CytokinesIBA
01/2020 - 04/2002
6IronIBA
01/2017 - 05/2003
6EnzymesIBA
01/2017 - 07/2007
6Pyruvate KinaseIBA
01/2017 - 12/2003
5pantetheinase (pantetheine hydrolase)IBA
01/2016 - 03/2007
4AzoxymethaneIBA
12/2019 - 03/2010
4Cysteamine (Mercaptamine)FDA Link
01/2016 - 08/2010
4AerosolsIBA
03/2009 - 01/2008
3Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
01/2020 - 01/2012
3RNA (Ribonucleic Acid)IBA
12/2019 - 01/2013
3Dextran SulfateIBA
12/2019 - 10/2010
3interferon regulatory factor-8 (interferon consensus sequence binding protein)IBA
10/2017 - 03/2009
3Messenger RNA (mRNA)IBA
02/2016 - 04/2002
3artemisinin (artemisinine)IBA
01/2016 - 08/2010
3InterferonsIBA
01/2015 - 11/2002
3VaccinesIBA
08/2011 - 06/2005
3Antimalarials (Antimalarial Agents)IBA
08/2011 - 08/2010
3Interleukin-12 (IL 12)IBA
06/2011 - 05/2006
3Adenosine Triphosphate (ATP)IBA
10/2009 - 11/2003
2Interferon Type IIBA
01/2017 - 11/2016
2ArtesunateIBA
01/2016 - 08/2010
2Virulence Factors (Pathogenicity Factors)IBA
09/2014 - 09/2006
2CarcinogensIBA
01/2013 - 06/2011
2Complement System Proteins (Complement)IBA
10/2012 - 08/2006
2InflammasomesIBA
12/2011 - 03/2010
2ProteomeIBA
12/2011 - 09/2006
2Membrane Proteins (Integral Membrane Proteins)IBA
03/2011 - 12/2004
2Biological ProductsIBA
08/2010 - 06/2005
2AntigensIBA
01/2009 - 03/2004
2Transcription Factors (Transcription Factor)IBA
03/2007 - 05/2006
1Programmed Cell Death 1 ReceptorIBA
01/2021
1Hemoglobins (Hemoglobin)IBA
01/2020
1Bisphosphoglycerate Mutase (Diphosphoglycerate Mutase)IBA
01/2020
1Oxyhemoglobins (Oxyhemoglobin)IBA
01/2020
1Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA
12/2019
1Retinaldehyde (Retinal)IBA
01/2018
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2017
1ArtemetherFDA Link
01/2016
1Drug CombinationsIBA
01/2016
1Sulfhydryl Compounds (Thiols)IBA
01/2016
1ArtemisininsIBA
01/2016
1artemotil (arteether)IBA
01/2016
1antiglomerular basement membrane antibodyIBA
03/2015
1Natural Killer Cell ReceptorsIBA
12/2014
1Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA
05/2014
1ChromatinIBA
01/2013
1ElementsIBA
10/2012
1Phosphotransferases (Kinase)IBA
01/2012
1FlagellinIBA
12/2011
1Complement C5 (Complement 5)IBA
12/2011
1Interferon-gamma (Interferon, gamma)IBA
06/2011
1artenimol (dihydroartemisinin)IBA
08/2010
1CaspasesIBA
03/2010
1CationsIBA
09/2009
1Factor VIII (Coagulation Factor VIII)IBA
03/2009
1AutoantigensIBA
01/2009
1Anaphylatoxin C5a ReceptorIBA
05/2008
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
02/2008
1Interleukin-12 Subunit p40IBA
08/2007
1Protein Isoforms (Isoforms)IBA
08/2007
1NLR ProteinsIBA
06/2007

Therapy/Procedure

2Therapeutics
01/2016 - 08/2010